N-ACYL-N'-(PYRIDIN-2-YL)CARBAMIDES AND THEIR ANALOGUES EXHIBITING ANTICANCER AND ANTIPROLIFERATIVE ACTIVITY Russian patent published in 2022 - IPC C07D401/14 C07D405/14 C07D413/14 C07D417/14 A61K31/44 A61P19/02 A61P35/00 

FIELD: pharmaceutics.

SUBSTANCE: invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, where in formula I A is selected from a group consisting of C1-C6-alkyl, deutero-C1-C6-alkyl, where the alkyl chain is partially or completely deuterated, branched C3-C8-alkyl, C3-C8-carbocyclyl, C6-C12-spirobicycloalkyl, adamantyl, bicyclo[2.2.1]heptanyl, bicyclo[2.2.2]octyl or 4–8-membered non-aromatic heterocyclyl, where at least one of the ring atoms of the non-aromatic heterocyclyl is O, and each fragment A can be further substituted with one, two or three fragments of R3; W is selected from the group consisting of pyrazolyl, imidazolyl, isoxazolyl, oxazolyl, thiazolyl, triazolyl, pyridinyl, phenyl, wherein each W is optionally substituted with one, two or three R5; each X1, X2 and X3 is individually and independently hydrogen or C1-C6-alkyl; Z1 is CX3; Z2 is CX1 or N; Z3 is CH; each R1 and R2 is individually and independently H or C1-C6-alkyl; R3 individually and independently represents H, halogen, C1-C6-alkyl, fluoro-C1-C6-alkyl, where the alkyl chain is partially or completely fluorinated, branched C3-C8-alkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, fluoro-C1-C6-alkoxy, where alkyl chain is partially or completely fluorinated, branched C3-C6-alkoxy, hydroxyl group or cyano group; R4 is individually and independently hydrogen, C1-C6 alkyl or branched C3-C8 alkyl; R5 individually and independently represents hydrogen, C1-C6-alkyl, deutero-C1-C6-alkyl, where the alkyl chain is partially or completely deuterated, or -(CH₂)_m-CN, wherein each alkyl or alkylene is optionally substituted with one or two C1-C6 alkyls; each of m, n and q is individually and independently equal to 0, 1, 2 or 3.

EFFECT: compound of formula I, having inhibitory action on c-FMS (CSF-1R), c-KIT and/or PDGFR kinases.

31 cl, 3 tbl, 176 ex