PYRAZOLOPYRIDINE DERIVATIVES AS KINASE INHIBITORS Russian patent published in 2020 - IPC C07D471/04 A61K31/437 A61K31/496 A61P29/00 A61P31/12 A61P33/06 A61P35/00 A61P37/06 

FIELD: organic chemistry.

SUBSTANCE: invention relates to a heterocyclic compound of formula (IA) or a pharmaceutically acceptable salt or solvate thereof, in which Q denotes a group of formula (Qa), in which the sign of the sprocket (*) indicates the position of attachment to the rest of the molecule; Y represents -C(O)N(R⁴)-; Z is aryl, selected from phenyl, or heteroaryl, selected from pyrazine, imidazopyridine, pyridine, any of these groups may optionally contain one or two substitutes independently selected from a group comprising halogen, cyano, C₁-C₆-alkyl, trifluoromethyl, dihalogen-azetidine, C₁-C₆-alkoxy group, difluoromethoxy group, trifluoromethoxy, di(C₁-C₆)alkylamino; A¹ denotes C₁-C₆-alkyl optionally substituted with -OR^a; A², R⁴, R¹² and R^a denote hydrogen; R¹¹ denotes hydrogen or an amino group; R¹³ denotes C₁-C₆-alkyl. Invention also relates to a pharmaceutical composition based on the compound of formula (IA).

EFFECT: obtaining novel pyrazolo[3,4-b]pyridine derivatives useful as inhibitors of phosphatidyl inositol-4-kinase IIIβ activity (PI4KIIIβ).

11 cl, 39 ex