COMBINED PREPARATIONS OF AMINOGLYCOSIDES AND PHOSPHOMYCIN, HAVING IMPROVED CHEMICAL PROPERTIES Russian patent published in 2019 - IPC A61K31/7036 A61K31/665 A61K9/08 A61P31/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to pharmaceutical industry, namely to an antibiotic pharmaceutical composition and a combination. Antibiotic pharmaceutical combination contains bactericidal concentrations of aminoglycoside solution and phosphomycin solution, each of which is tightly packed in sterile container, difference in pH value of two solutions is less than 2.0, and the concentration of the chloride anion in the combined solution containing the aminoglycoside solution and the phosphomycin solution is at least 40 mEq/l. Multicomponent antibiotic composition contains a first component comprising an aminoglycoside solution having a first pH in range of 6.5 to 7.5; a second component comprising a phosphomycin solution having a second pH value in range of 7.5 to 8.5, a difference between the first and second pH values of less than 2.0, and the concentration of the chloride anion in the combined solution containing the first component and the second component is at least 30 mEq/l.

EFFECT: disclosed composition and combination have improved bacteriostatic and/or bactericidal properties.

18 cl, 2 dwg, 5 ex