VISCOELASTIC GELS AS NOVEL FILLERS Russian patent published in 2019 - IPC A61L27/26 A61L27/52 A61L27/58 C08L5/08 

FIELD: medicine.

SUBSTANCE: group of inventions relates to a method of producing and purifying a derivative (HBC) of hyaluronic acid, involving the following steps: a) dissolving an alkaline solution of diepoxide of diglycidyl ether 1,4-butanediol (BDDE) in stoichiometric ratio of 2.5 to 25 % mole of repeating links of hyaluronic acid, followed by b) dispersing hyaluronic acid (HA) in the solution specified in subparagraph (a) at room temperature, c) starting the reaction by thermal activation of the solution specified in subparagraph (b), heated at temperature of 35 to 55 °C for 2 to 36 hours, d) extruding the obtained mass through a metal sieve to reduce its particles to a size of approximately 600 mcm, e) hydrating the obtained gel by diluting with water 3 to 20 times, f) adjusting pH to neutral with an aqueous solution of HCl, g) depositing a water-soluble organic solvent, such as ethanol, methanol, isopropanol, n-propanol, dioxane, acetonitrile, acetone and/or mixtures thereof, until a product in form of a precipitated powder is obtained, h) washing with organic solvents, such as ethanol, methanol, isopropanol, n-propanol, dioxane, acetonitrile, acetone and/or mixtures thereof, containing water, i) drying in vacuum until removal of residual solvents below 400 ppm and obtaining white HBC powder; method of producing a biomaterial consisting of a mixture of hyaluronic acid hexadecylamide (HYADD) with HBC; to a method of producing and purifying an HBC derivative, comprising steps of: a) dissolving BDDE diepoxide in alkaline solution in stoichiometric ratio of 2.5 to 25 mole of repeating links of hyaluronic acid, followed by b) dispersing HA in the solution specified in the previous subparagraph a) at room temperature, c) triggering the reaction by thermal activation, wherein the solution specified in subparagraph (b) is heated at 35 to 55 °C for 2 to 36 hours, d) bringing the pH to neutral with an aqueous solution of HCl, e) hydrating the obtained gel by diluting with water 3 to 20 times; method of producing a biomaterial consisting of a mixture of HYADD and HBC; to a biomaterial consisting of a mixture of HYADD with HBC, cross-linked with BDDE in weight ratio of 10:90 to 90:10, as a new filler and/or as a body profiling product; to application of biomaterial as new filler and/or new product for body profiling in treatment of skin defects, in dermatology, in dermatocosmetology and/or aesthetic surgery.

EFFECT: group of inventions provides possibility of immediate regeneration/recovery of dermal/skin tissue, which lost its initial density.

14 cl, 2 dwg, 16 ex