SPLIT-RESISTANT LOW MOLECULAR CROSS-LINKED HYALURONATE Russian patent published in 2017 - IPC A61K8/73 A61K47/36 C08L5/08 A61L27/52 A61K31/728 

FIELD: biotechnology.

SUBSTANCE: hydrogel is formed by sodium hyaluronate substrate with an average molecular weight of 50,000 to 100,000 Da, cross-linked with diglycidyl ether of 1,4-butanediol, which is obtained by a method comprising interaction of 8-40% solution of sodium hyaluronate with an average molecular weight of 50,000 to 100,000 Da in 0.75-1.5% aqueous solution of sodium hydroxide with the diglycidyl ether 1,4-butanediol volume of 180 to 500 moles per one mole of sodium hyaluronate.

EFFECT: product has a high resistance to enzymatic degradation.

14 cl, 15 dwg, 5 tbl, 14 ex