NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND USE THEREOF IN MEDICINAL PREPARATIONS Russian patent published in 2019 - IPC C07D401/10 C07D401/14 C07D405/14 C07D417/14 C07D409/14 C07D413/10 A61K31/506 A61K31/5377 A61P1/16 A61P11/00 A61P13/08 A61P13/12 A61P17/00 A61P21/00 A61P25/28 A61P35/00 A61P41/00 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a novel compound of formula (II), which has the properties of a cell proliferation inhibitor. Fabric or organ fibrosis is renal interstitial fibrosis, glomerulosclerosis, hepatic fibrosis, pneumosclerosis, IPF, peritoneal fibrosis, myocardial fibrosis, dermatofibrosis, skeletal muscle fibrosis, pancreatic fibrosis, hepatic cirrhosis, myosarcoma, neurofibroma, pulmonary interstitial fibrosis, or vascular fibrosis. In formula (II)

,

where each of Q¹ and Q² independently represents N or CH; J is -O- or -(CH₂)_m-; Y is -O-, -(CH₂)_m-O-, -N(R⁶) - or -(CH₂)_m-; where each is (CH₂)_m-O- and -(CH₂)_m- independently and optionally substituted with one or more substitutes independently selected from C_1-4 alkyl, each R⁵ independently represents

,

where each E¹, E² and E³ independently represents N or CR⁷; each T and T¹ independently represents -NR⁸-, -O-, -S- or -CR⁷R^7a-; each R⁷ and R^7a independently represents H; where each R⁵ independently and additionally substituted with one or more substituents independently selected from H, F, Cl, Br, I, C_1-4 alkyl, C_2-4 alkenyl, C_1-4 alkoxy, C_1-4 haloalkyl, cyano, amino, C_1-4 alkylamino, phenyl, and C_1-4 haloalkoxy; each R⁶ independently represents H or C_1-4 alkyl; each R⁸ independently represents H; each R^1a is independently H, F, Cl, Br, or I; R³ is methyl, ethyl, propyl, butyl, or tert-butyl; and each R⁴ is independently H, F, Cl, Br, or I; each m is independently 1 or 2; and each n or p is independently 0, 1, 2, 3 or 4.

EFFECT: compound can be used in preparing a medicinal agent for preventing, controlling, treating or relieving the severity of tissue or organ fibrosis.

11 cl, 1 tbl, 69 ex