SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE Russian patent published in 2018 - IPC C07D403/12 C07D403/14 C07D413/14 C07D401/14 A61K31/517 A61P11/06 A61P11/00 A61P29/00 A61P37/08 A61P17/00 A61P19/02 A61P31/02 A61P9/02 A61P25/28 A61P1/04 A61P37/06 

FIELD: chemistry.

SUBSTANCE: invention relates to novel aminopyrimidine compounds of formula (I) having the properties of an inhibitor of PI3-kinase, in particular PI3Kδ. Compounds are intended to regulate, treat or alleviate the severity of a disease caused by inadequate PI3 kinase activity by administering a therapeutically effective amount of the compound. In compounds of formula (I) X is a monovalent heteroaryl group selected from the structures: and where X is substituted with 1 or 2 R¹ groups; Y is , each R¹ is independently H, -C(= O)NR^aR^b, (C₁-C₆)alkyl or (C₃-C₈)cycloalkyl; R³ is H; R⁴ is (C₁-C₆)alkyl; and R^a and R^b are independently H, (C₁-C₃)alkyl, (C₂-C₄)alkenyl, (C₂-C₄)alkynyl, (C₃-C₆)cycloalkyl, (C₃-C₅)heterocyclyl or 5-6-membered heteroaryl, where each of (C₁-C₃)alkyl, (C₂-C₄)alkenyl, (C₂-C₄)alkynyl, (C₃-C₆)cycloalkyl, (C₃-C₅)heterocyclyl and 5-6 membered heteroaryl is substituted with 1, 2, 3 or 4 substituents independently selected from F, CN, OH, NH₂, (C₁-C₃)alkyl, (C₁-C₃)haloalkyl, (C₁-C₃)alkoxy and (C₁-C₃)alkylamino.

EFFECT: compounds can be used to treat diseases such as asthma, chronic obstructive pulmonary disease (COPD), viral respiratory infections, viral exacerbations of respiratory diseases, aspergillosis, leishmaniasis, allergic rhinitis,

atopic dermatitis, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, hemoblastosis, pancreatitis, nephropathy, carcinoma, graft rejection, tissue rejection, lung injury, pain caused by rheumatoid arthritis, osteoarthritis, back pain, pain caused by a common inflammatory process, post-hepatic neuralgia, diabetic neuropathy, inflammatory neuropathic pain (trauma), trigeminal neuralgia or central pain.

12 cl, 5 tbl, 70 ex