METHODS OF PRODUCING ADJUVANTED VIROSOME AND ADJUVANTED VIROSOMES, OBTAINED BY SAID METHODS Russian patent published in 2019 - IPC A61K39/12 A61K39/39 A61K47/69 

FIELD: medicine.

SUBSTANCE: group of inventions refers to medicine, namely to immunology, and can be used for production of virosome adjuvants. Method of producing virosome adjuvants involves the following stages: (I) providing an aqueous composition which is uniaxial to virosomes, containing a membrane fusion protein; (II) dissolving an amphiphilic adjuvant in a pharmaceutically acceptable non-aqueous solvent which can form a homogeneous mixture with water; and (III) diluting said adjuvant solution in said aqueous virosome composition to induce incorporation of the adjuvant into the outer layer of the virosomal membrane while maintaining the ability of said virosome to fuse with the membrane. Group of inventions refers to pharmaceutical and immunogenic compositions containing an adjuvant virosome prepared by the above method, as well as to methods of immunization of a subject of cancer or viral disease.

EFFECT: there are presented methods for producing adjuvanted virosome and adjuvanted virosomes, obtained by said methods.

34 cl, 3 ex, 8 dwg