FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to compounds of formula (I), where values of R1–R5, X, Q and n are presented in the claim, which relate to modulators of protein functions, providing recovery of protein homeostasis, including activity of cytokines, Aiolos and/or Ikaros and intercellular adhesion. Also disclosed are pharmaceutical compositions containing said compounds, and use of compounds for treating or preventing diseases, disorders or conditions mediated by cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel disease, Crohn's disease, ulcerative colitis, uveitis, pulmonary inflammatory diseases, chronic obstructive pulmonary disease, Alzheimer's disease and cancer.
.
EFFECT: disclosed are protein-targeted compounds, their compositions, methods and uses aoolications.
15 cl, 14 dwg, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| THIENOPYRROL DERIVATIVES FOR APPLICATION FOR TARGETING PROTEINS, COMPOSITIONS WITH SAID DERIVATIVES, METHODS AND APPLICATIONS | 2017 |
|
RU2771166C2 |
| TRAF 6 INHIBITORS | 2017 |
|
RU2770404C2 |
| MEK INHIBITORS AND THEIR THERAPEUTIC USE | 2021 |
|
RU2812929C1 |
| BENDAMUSTINE DERIVATIVES, RELATED COMPOUNDS AND THEIR MEDICAL APPLICATION FOR TREATING CANCER | 2013 |
|
RU2695383C2 |
| NEW SUBSTITUTED 8-HETEROARYLXANTINES AND BASED PHARMACEUTICAL COMPOSITION | 2004 |
|
RU2357969C2 |
| HYDROXAMATE DERIVATIVES SUITABLE AS DEACETYLASE INHIBITORS | 2001 |
|
RU2302408C2 |
| SERINE-THREONINE PROTEIN KINASE AND PARP MODULATORS | 2013 |
|
RU2681209C2 |
| PROLYL HYDROXYLASE INHIBITORS | 2010 |
|
RU2518071C2 |
| PYRAZOLE DERIVATIVES APPLIED AS PROTEIN KINASE INHIBITORS | 2001 |
|
RU2340611C2 |
| SELECTIVE ESTROGEN RECEPTOR INHIBITORS AND USE THEREOF | 2017 |
|
RU2734501C2 |
