TRAF 6 INHIBITORS Russian patent published in 2022 - IPC C07D487/04 A61K31/5025 A61P17/06 A61P35/00 A61P37/00 

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely, to an application of a compound by the formula (I) for inhibiting interaction of TRAF6 with UBC13, wherein X is selected from the group consisting of N and CH; R¹ is selected from the group consisting of hydrogen, a (C₁-C₆)alkyl, a (C₁-C₆)halogenalkyl; R² and R³ are independently selected from the group consisting of a linear (C₁-C₆)alkyl; n constitutes 2; Z is selected from the group consisting of C=O; Z is C=O; A is selected from the group consisting of –N(R⁴)(R⁵) and R⁴ constitutes hydrogen or a (C₁-C₆)alkyl; R⁵ is selected from the group consisting of a (C₆-C₁₀)aryl(C₁-C₆)alkyl, a furanyl(C₁-C₆)alkyl, a thiophenyl(C₁-C₆)alkyl, and an indolyl(C₁-C₆)alkyl, optionally substituted with one or more identical or different substituents selected from the group consisting of halogen, a (C₁-C₄)alkyl; R⁶ constitutes a (C₁-C₄)alkyl; Y is selected from the group consisting of N-B, CH-B, and O; B is selected from the group consisting of a (C₆-C₁₀)aryl, pyridinyl, a (C₆-C₁₀)aryl(C₁-C₆)alkyl, a pyridinyl(C₁-C₆)alkyl, a furanyl(C₁-C₆)alkyl, and a (C₁-C₆)alkyl, optionally substituted with one or more identical or different substituents selected from the group consisting of halogen, a (C₁-C₄)alkyl, a (C₁-C₄)halogenalkyl, and -OR⁶; p and q constitutes an integer from 1 to 2. The invention also relates to a compound by the formula (I), wherein the values of radicals have the values specified in the claim, and specific compounds.

EFFECT: inhibition of interaction of TRAF6 with UBC13 by a compound by the formula (I) in treatment of arthritis, psoriasis, and some types of cancer.

12 cl, 20 dwg, 2 tbl