NOVEL 3,5-DIVINYL-PYRAZOLE DERIVATIVES FOR MEDICAL USE Russian patent published in 2019 - IPC C07D231/12 C07D403/10 C07D405/06 A61K31/415 A61K31/4155 A61K31/4178 A61P35/00 

FIELD: medicine; pharmacology.

SUBSTANCE: invention refers to pharmacology, and concerns new chemical compounds of general formula (I) or their pharmaceutically acceptable salts which are inhibitors of P-glycoprotein. In formula (I) R₁, R₂, R₃, R₄ independently represent H, halogen, NO₂; R_x - is selected from -C(=S)NHR^A, -C(=O)OR^A, -S(=O)₂NR^AR^B, -C(=O) NR^AR^B, 5-membered partially or completely unsaturated heterocycle containing 2 N atoms; R^A is independently selected and represents C_1-6-alkyl, partially or completely halogenated C_1-8-alkyl; R^B is independently selected and represents H, C_1-8-alkyl or partially or completely halogenated C_1-8-alkyl; alternatively, in case R_x is -C (= O) NR^AR^B, R^A and R^B together with nitrogen atom, to which they are attached, can form saturated cycle containing 5 atoms; R_p is independently selected and represents C_1-6-alkyl, partially or completely halogenated C_1-6-alkyl; R_m is selected independently and is H, C_1-6-alkyl, partially or completely halogenated C_1-8-alkyl; alternatively neighbouring groups R_p and R_m together with two oxygen atoms, to which they are attached, and two carbon atoms of the benzene ring can form a non-aromatic ring containing 5 to 6 atoms. Given chemical compounds can be used to suppress multiple drug resistance in the patients receiving the various drugs for a long time. Invention also relates to the use of the above compounds and a pharmaceutical composition containing said compounds.

(I).

EFFECT: these compounds can be used in therapy of central nervous system diseases, infectious, allergic, autoimmune, oncological and other diseases.

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