NEW CHEMICAL COMPOUNDS (VERSIONS) AND USING THEM FOR TREATING ONCOLOGICAL DISEASES Russian patent published in 2015 - IPC C07D487/04 A61K31/5025 A61P35/00 

Abstract RU 2550346 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new chemical compounds of general formula I wherein LA, LB, LC, cycle A, cycle B, RA, RB, RC, RD, RE and RF have the values specified in the patent claim. The compounds of formula (I) are protein kinase inhibitors.

EFFECT: invention refers to pharmaceutical compositions containing the above compounds, as well as to using the above compounds for treating and/or preventing the diseases related to aberrant protein kinase activity, particularly oncological diseases.

10 cl, 14 tbl, 25 ex

Similar patents RU2550346C2

Title Year Author Number
NEW METHOD OF SYNTHESIS OF TETRAHYDROPYRASIN[2,3-C]PYRIDAZINE DERIVATIVES 2016
  • Titov Ilya Yurevich
  • Stroganov Oleg Valentinovich
  • Chilov Germes Grigorevich
  • Strojlov Viktor Sergeevich
  • Novikov Fedor Nikolaevich
RU2631430C1
SUBSTITUTED PYRIDINES AND PYRIDAZINES WITH ANGIOGENESIS INHIBITION ACTIVITY 2000
  • Djuma Zhak P.
  • Dzho Teddi Kajt
  • Kljuehnder Khehrold K.I.
  • Li Vendi
  • Nagaratkhnam Dkhanapalan
  • Sibli Robert N.
  • Su Ning
  • Bojer Stefen Dzhejms
  • Dikson Zhuli A.
RU2260008C2
IMIDAZO[1,2-b]PYRIDAZINE AND PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AND USE THEREOF AS PROTEIN KINASE INHIBITOR 2007
  • Birss Dehvid Dzh.
  • Lju Sjao-Khoj
  • Vankajalapati Khariprasad
  • Sjuj Jun
RU2487875C2
PYRIDAZINONE MACROCYCLES AS IRAK-KINASE INHIBITORS AND USE THEREOF 2016
  • Chen, Xiaoling
  • Lan, Ruoxi
  • Jorand-Lebrun, Catherine
  • Yu, Henry
  • Goutopoulos, Andreas
RU2708066C2
SUBSTITUTED PIRIDAZINE-CARBOXAMIDE COMPOUNDS AS KINASE-INHIBITING COMPOUNDS 2009
  • Liang Kongksin
  • Li Zhigang
RU2526618C2
mTOR KINASE INHIBITORS FOR ONCOLOGICAL INDICATIONS AND DISEASES METABOLICALLY BOUND TO mTOR/PI3K/AKT 2009
  • Ehl'Sner Jan
  • Kharris Roj L.
  • Li Brehnden
  • Mortensen Debora
  • Pakard Garrik
  • Papa Patrik
  • Perren-Ninkovich Sofi
  • Riggs Dzhennifer
  • Sankar Sabita
  • Sapienza Dzhon
  • Shevlin Graziehlla
  • Terani Lida
  • Sjuj Vehjmin
  • Chzhao Tszintszin
  • Parnes Dzhejson
  • Madakamutil Lui
  • Fults Kimberli
  • Narla Rama K.
RU2546658C2
CONDENSED AZA-HETEROCYCLIC AMIDE COMPOUND AND ITS USE 2021
  • Mi, Gozhuj
  • Chzhan, Yan
  • Tszyan, Chunkhua
  • Syuj, Yansya
  • Fan, Lisyue
  • Chzhan, Syuetszyao
  • Tsin, Yanan
RU2811975C1
BI- AND POLYCYCLIC SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES, USEFUL AS RHO-KINASE INHIBITORS 2009
  • Plettenburg Oliver
  • Lorents Katrin
  • Len Mattias
  • Djuklo Oliv'E
  • Biskarra Sandrin
RU2532481C2
COMPOUNDS AND METHODS FOR KINASE MODULATION AND INDICATIONS FOR THEIR USE 2013
  • Vu Guosyan
  • Chan Katrina
  • Eving Todd
  • Ibrakhim Prabkha N.
  • Lin Dzhek
  • Nespi Marika
  • Spevak Vejn
  • Chzhan In
RU2666146C2
NOVEL 3-PHENYLPROPIONIC ACID DERIVATIVES FOR TREATING DIABETES 2005
  • Majka Zbignev
  • Stavinski Tomash
  • Rusin Katarzhina
  • Savitski Andzhej
  • Kurovski Kshishtof
  • Matusievich Katarzhina
  • Sulikovski Daniehl'
  • Koval'Chik Petr
RU2360906C2

RU 2 550 346 C2

Authors

Chilov Germes Grigor'Evich

Stroganov Oleg Valentinovich

Strojlov Viktor Sergeevich

Novikov Fedor Nikolaevich

Zejfman Aleksej Aleksandrovich

Titov Il'Ja Jur'Evich

Dates

2015-05-10Published

2013-09-26Filed