N4-PHENYLQUINAZOLINE-4-AMINE DERIVATIVES AND RELATED COMPOUNDS AS RECEPTOR TYROSINE KINASE TYPE ERBB INIHIBITORS FOR TREATING HYPERPROLIFERATIVE DISEASES Russian patent published in 2011 - IPC C07D413/14 C07D417/14 C07D401/14 C07D403/14 C07D403/12 C07D413/12 C07D417/12 C07D471/04 C07D495/14 A61K31/517 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of formula I or pharmaceutically acceptable salts thereof, which have receptor tyrosine kinase type I inhibiting properties and can be used in treating hyperproliferative disorders in mammals. In general formula

,

A is O or S; G is N; B is a 6-member aryl or 5-6-member heteroaryl ring containing a sulphur atom as a heteroatom; E is

, , , , , X is N or CH; D¹, D² and D³ independently denote N or CR¹⁹; D⁴ and D⁵ independently denote N or CR¹⁹ and D⁶ is O, S or NR²⁰, where at least one of D⁴ and D⁵ is CR¹⁹; D⁷, D⁸, D⁹ and D¹⁰ independently denote N or CR¹⁹, where at least one of D⁷, D⁸, D⁹ and D¹⁰ is N; R¹ is H or C₁-C₆ alkyl; each R² independently denotes halogen, cyano, nitro etc, trifluoromethyl, difluoromethyl, fluoromethyl, fluoromethoxy, difluoromethoxy, trifluoromethoxy, azido, -SR¹⁸, -OR¹⁵, -C(O)R¹⁵, -C(O)OR¹⁵, -NR¹⁴C(O)OR¹⁸, -OC(O)R¹⁵, -NR¹⁴SO₂R¹⁸, -SO₂NR¹⁵R¹⁴, -NR¹⁴C(O)R¹⁵, -C(O)NR¹⁵R¹⁴, -NR¹⁵C(O)NR¹⁵R¹⁴, -NR¹³C(NCN)NR¹⁵R¹⁴, -NR¹⁵R¹⁴, C₁-C₁₂alkyl, C₂-C₁₂ alkenyl, alkynyl, saturated or partially unsaturated C₃-C₁₀cycloalkyl, C₃-C₁₀cycloalkyl-C₁-C₁₂alkyl, -S(O)p(C₁-C₆alkyl), -S(O)p(CR¹³R¹⁴)q-phenyl, phenyl, phenyl-C₁-₃-alkyl, 5-6-member heteroaryl, 5-6-member heteroaryl-C₁-C₃-alkyl, saturated or partially unsaturated 3-8-member heterocyclyl, 5-6-member heterocyclyl-C₁-C₃-alkyl, -O(CR¹³R¹⁴)q-phenyl, NR¹⁵(CR¹³R¹⁴)q-phenyl, O(CR¹³R¹⁴)q-(5-6-member heteroaryl), NR¹³(CR¹³R¹⁴)q-(5-6-member heteroaryl, -O(CR¹³R¹⁴)q-(3-8-member heterocyclyl) or -NR¹⁵(CR¹³R¹⁴)q-3-8-member heterocyclyl), each R³ denotes Z, where Z is selected from and , W is O or S; W² is O or S;V is CR⁸R⁹, R^8b is H or C₁-C₆alkyl; each of R⁶, R⁸, R^8a and R⁹ independently denotes hydrogen, trifluoromethyl, C₁-C₁₂alkyl etc.

EFFECT: improved properties and high efficiency of using the compounds.

25 cl, 13 dwg, 1 tbl, 36 ex