5,5-HETEROAROMATIC ANTI-INFECTIOUS COMPOUNDS Russian patent published in 2019 - IPC C07D513/04 C07D498/04 C07D487/04 C07D407/12 C07D413/12 A61K31/429 A61K31/4188 A61K31/4427 A61K31/5377 A61P31/04 A61P31/06 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (A) or a pharmaceutically acceptable salt thereof, where X¹ is CH or N; X² is S; Z is -C(=O)NH-, -C(=O)O-; n ranges from 0 to 1; R¹ is (C₁-C₆)alkyl, halogen or trifluoromethyl; R² is (C₁-C₆)alkyl or trifluoromethyl; R³ is C₆aryl, which can be unsubstituted or contain a substitute selected from a group consisting of: C₁ alkoxy, which can be further substituted with halogen, halogen, oxy-C₆ aryl substituted with halogen, C₆ aryl substituted with halogen, morpholinyl, pyrrolidinyl, and di-C₁-C₆-alkylamino, wherein in case C₆ aryl is substituted with morpholinyl, it can contain second substitute, which is halogen. Invention also relates to specific compounds, a pharmaceutical composition based on compound of formula (A) or specific compound, use thereof and a method of killing or inhibiting mycobacterium growth, based on using the compound of formula (A) or a specific compound.

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EFFECT: technical result is obtaining novel heterocyclic compounds useful for treating mycobacterial infections.

12 cl, 1 dwg, 3 tbl, 4 ex