N-HYDROXYLSULPHONAMIDE DERIVATIVES AS NOVEL PHYSIOLOGICALLY USEFUL NITROXYL DONORS Russian patent published in 2013 - IPC C07C311/48 C07D295/104 C07D295/192 C07D295/26 C07D413/12 A61K31/195 A61K31/5375 A61K31/5377 A61P9/04 A61P9/10 

FIELD: chemistry.

SUBSTANCE: invention relates to N-hydroxylsulphonamide derivatives of formula or , where R¹ is H; R² is H; n is 0; b is an integer in the range of 1-4; R³, R⁴, R⁵, R⁶ and R⁷ are independently selected from H, halogen, carboxyl, carboxyl ester selected from a group including -C(O)O-morpholino, -C(O)O-C₁-C₈alkyl and -C(O)O-substituted C₁-C₈alkyl, where the substitute is morpholino; acylamino, which is a -C(O)NR^aR^b group, where R_a and R_b are independently C₁-C₈alkyl, or R_a and R_b together with a nitrogen atom to which they are bonded form morpholino; and sulphonylamino, which is a SO₂NR₂ group, where two groups R, together with a nitrogen atom to which they are bonded, form morpholino; R⁸ is selected from halogen and carbonylamino, selected from a -CONH-substituted C₁-C₈alkyl, where the substitute is morpholino; and -CONR₂, where two groups R, together with a nitrogen atom to which they are bonded, form morpholino; C is a heteroaromatic ring which contains cyclic fragments Q⁹, Q¹⁰, Q¹¹, Q¹², Q¹³ and Q¹⁴, which are independently selected from C, CH and S, under the condition that at least one of the fragments Q⁹, Q¹⁰, Q¹¹, Q¹², Q¹³ and Q¹⁴ is S. The invention also relates to a method of modulating nitroxyl levels, a method of treating diseases which respond to treatment with nitroxyl, a treatment set and a pharmaceutical composition containing compounds of formula (I) or (III).

EFFECT: compounds of formula (I) or (III) for treating diseases which respond to treatment with nitroxyl.

20 cl, 5 ex, 4 tbl, 7 ex