IMIDAZO[1,2-A]PYRIDINE COMPOUNDS, SYNTHESIS THEREOF AND METHODS OF USING SAME Russian patent published in 2017 - IPC C07D471/04 C07D487/04 A61K31/437 A61K31/519 A61P31/06 A01N43/50 A01P3/00 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically to novel imidazole derivatives of formula given below or pharmaceutically acceptable salt thereof, where Y denotes CH or N; R1 is: -alkyl containing 1-2 carbon atoms; - substituted alkyl containing 1-3 carbon atoms, which includes 1-3 substitutes, selected from a heteroaryl (selected from pyridine, thiazole furan), phenyl, halogen, wherein said heteroaryl and phenyl are substituted with 1-3 substitutes, selected from halogen, -OQ₁₀, methylsulphonyl group, fluorophenox group and Q₁₅; wherein Q₁₀ is an alkyl containing 1-3 carbon atoms, and Q₁₅ is hydrogen, alkyl containing 1-2 carbon atoms, which can be substituted with three halogen atoms; - cycloalkyl containing 3-6 carbon atoms; - amide (-CONH₂) or alkyne containing 2-4 carbon atoms; -halogen; -phenyl; -substituted phenyl, containing 1-2 substitutes, selected from trifluoromethylphenoxy group, -OQ₁₀, halogen, thiomorpholine; wherein Q₁₀ is an alkyl, containing one carbon atom; -benzotriazole; R₂ is: -alkyl, containing one carbon atom; -substituted alkyl, containing one carbon atom, containing 1-3 substitutes, selected from halogen and phenyl; -phenyl; R₃ is -COW, where W is OR₁, NHR₁ or NR₁R₂. Invention also relates to a pharmaceutical composition based on a condensed imidazole derivative and use of said compound.

EFFECT: technical result is obtaining novel condensed imidazole derivatives, useful in treatment or prevention of tuberculosis.

19 cl, 4 dwg, 5 tbl