FIELD: chemistry.
SUBSTANCE: present invention relates to a composite preparation and a method for production thereof, wherein the composite preparation comprises an internal portion comprising a first active ingredient selected from a phosphodiesterase-5 or tamsulosin inhibitor or a pharmaceutically acceptable salt thereof, and a film coating layer comprising a second active ingredient selected from 5-α-reductase, wherein the film coating layer comprises a graft copolymer of polyvinyl alcohol and polyethylene glycol and polyvinyl alcohol, wherein the weight ratio of the amount of the graft copolymer of polyvinyl alcohol and polyethylene glycol to the amount of polyvinyl alcohol ranges from 7:3 to 4:6.
EFFECT: disclosed is a composite preparation comprising a film coating layer containing an active ingredient.
10 cl, 8 dwg, 8 tbl, 9 ex
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