FIELD: medicine.
SUBSTANCE: group of inventions relates to methods and compositions for inhibiting the contraction of muscles and, in particular, to methods and compositions for inhibiting the contraction of smooth muscles of the urinary bladder. Method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising acetaminophen and one or more additional active ingredients selected from a group, comprising of α-blockers and 5α-reductase inhibitors. Group of inventions also relates to pharmaceutical compositions containing acetaminophen and one or more αblocker or acetaminophen and one or more 5α-reductase inhibitor, in which acetaminophen is made for prolonged release, and one or more αblockers and one or more 5α-reductase inhibitors - for immediate release.
EFFECT: this allows to reduce a rate of urination due to inhibition of smooth muscle contraction of the urinary bladder.
36 cl, 9 tbl, 8 ex, 2 dwg
