METHODS OF TREATING ATOPIC DERMATITIS WITH THE HELP OF IL-4R ANTAGONIST Russian patent published in 2019 - IPC A61K38/02 A61P17/04 

FIELD: medicine.

SUBSTANCE: declared group of inventions refers to medicine and pharmacology and represents a pharmaceutical composition containing a therapeutically effective amount of an antibody to human interleukin-4 (IL-4R) receptor or its antigen-binding fragment for treating, reduction of intensity, easing, alleviation or prevention of skin itching in a patient, where the patient suffers from moderately severe to severe atopic dermatitis (AD), where a patient suffering from moderately severe to severe atopic dermatitis is resistant to treatment with a topical corticosteroid or calcineurin inhibitor, wherein the antibody or antigen-binding fragment thereof contains complementarity determining regions (CDR) of heavy and light chains in a pair of amino acid sequences of a heavy chain variable region / light chain variable region (HCVR/LCVR) containing SEQ ID NO: 162/164, and a method of treating, reducing the intensity, relieving or preventing skin itching in a patient, wherein the patient suffers from moderately severe to severe atopic dermatitis (AD), comprising administering the above pharmaceutical composition to said patient.

EFFECT: declared group of inventions provides high clinical effectiveness, reduced intensity, relief, relief or prevention of skin itching in a patient, where the patient suffers from moderately severe to severe atopic dermatitis.

19 cl, 56 dwg, 47 tbl, 12 ex