FURO[3,2-C]PYRIDINE OR THIENO[3,2-C]PYRIDINE DERIVATIVES USEFUL IN TREATING NOCTURIA Russian patent published in 2019 - IPC C07D491/48 C07D495/04 A61K31/4355 A61K31/4365 A61P13/02 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to a heterocyclic compound of formula (I), or a pharmaceutically acceptable salt thereof, where X is O or S; dotted line denotes double chemical bond; R¹ is lower alkyl, which optionally has one substitute selected from group G¹, C₅cycloalkyl, or -low alkylene-(C₃cycloalkyl); R² and R⁵ are identical or different from each other and represent H or lower alkyl; R³ is -low alkylene-X³-lower alkyl, -lower alkylene-X³-lower alkylene-C_3-4cycloalkyl, -lower alkylene-C_3-4cycloalkyl, or -low alkylene-X³-C₄cycloalkyl; X³ is O or S(O)_n, where n is 0, 1 or 2; R⁴ is OH, NH₂ or -O-lower alkyl, and R⁶ is H; or R⁴ and R⁶ are linked to form together with -C(=O)-CO-, to which they are attached, 2,2-di(lower alkyl)-4-oxo-1,3-dioxolane-5,5-diyl; group G¹ consists of halogen and OH. Invention also relates to a pharmaceutical composition based on the compound of formula (I), use of the compound of formula (I) and a method of treating nocturia.

(I).

EFFECT: technical result is obtaining novel heterocyclic compounds useful for inhibiting P-LAP.

19 cl, 21 tbl, 27 ex