METHOD OF PREPARING TETRAHYDROFURO[3,2-c]PYRIDINES Russian patent published in 2023 - IPC C07D491/48 

FIELD: organic chemistry.

SUBSTANCE: invention relates to a method of producing substituted tetrahydrofuro[3,2-c]pyridines of general formula I, which can be used as substances with potential biological activity of a wide spectrum of action. The method is carried out by the interaction of readily available 2-(5-methylfuran-2-yl)ethylamine and substituted benzaldehydes by boiling in acetonitrile with the formation of the corresponding imines and subsequent cyclization of the resulting imines in acetic acid at 70°C in the presence of concentrated hydrochloric acid, followed by treatment of the reaction mixture with NaOH solution at a room temperature to form the target tetrahydrofuro[3,2-c]pyridines Ia-i.

EFFECT: creation of a simple and effective method of the synthesis of substituted tetrahydrofuro[3,2-c]pyridines of formula Ia-i, which makes it possible to obtain the target products in good yields, as well as to vary the substituents in the 4th position of the heterocyclic ring.

1 cl, 2 tbl, 5 ex