FIELD: medicine.
SUBSTANCE: group of inventions relates to medical equipment, namely to an inhalation device for delivering a spray aerosol to a patient, an assembly unit, a combination, a kit and a method of delivering a spray aerosol to a patient. Inhalation device comprises (a) an aerosol generator with a vibration grid. Device includes (b) a reservoir for liquid to be sprayed. Reservoir is in fluid communication with the vibration grid. Device has (c) an inlet for gas in the form of a pipe nozzle and (d) a face mask. Mask comprises a body, an aerosol inlet, a patient's contact surface and a one-way expiration valve or a two-way inhalation/expiration valve in the body that has expiration resistance selected in range of 0.5 to 5 mbar. Device comprises (e) a flow channel extending from the gas inlet to the aerosol inlet opening in the face mask. Flow channel has a lateral hole, through which the aerosol generator is at least partially inserted into the flow channel. Channel comprises constant flow resistance between gas inlet and face mask aerosol inlet at flow rate of 1 to 20 l/min. Flow channel does not have an additional inlet opening for receiving gas. Assembly comprises an inhalation device and a gas source which supplies gas at a constant flow rate in range of 1 to 5 l/min. Gas source is connected to the inhalation device so that gas enters the flow channel through the gas inlet, and the gas is selected from oxygen, air, oxygen-enriched air, a mixture of oxygen and nitrogen and a mixture of helium and oxygen. Combination comprises (a) an inhalation device or an assembly unit and (b) a pharmaceutical composition for inhalation use. Kit contains (a) an inhalation device or an assembly unit and (b) a pharmaceutical composition for inhalation use. Method of delivering a spray aerosol to a patient comprises (a) providing an inhalation device, (b) providing a gas source and (c) connecting the gas source to the inhalation device such that the gas enters the flow channel through the gas inlet at a constant flow rate in range of 1 up to 5 l/min.
EFFECT: technical result is improved delivery of a therapeutic aerosol to a patient who is not free to perform respiratory manoeuvres required for a standard inhalation therapy, such as a paediatric patient.
40 cl, 8 dwg
