FIELD: medicine.
SUBSTANCE: group of inventions refers to medicine, namely to determining a physiological state of a subject. Disclosed is a method of determining intrapleural pressure of a subject, involving: obtaining a first physiological parameter, which is a non-invasively measured pressure in the respiratory tract of the subject; obtaining a second physiological parameter, which is a non-invasively measured airflow into a subject's lungs; determining lung subject volume by means of mathematical integration of second physiological parameter; non-invasive assessment of the third physiological parameter, which is an intrapleural pressure of the subject, based on the first and second physiological parameters and volume of the lungs, generating a signal which is this parameter. Also disclosed is a method of determining the operation of respiration, involving: obtaining a non-invasively assessed intrapleural pressure of the subject; determining a lung subject volume based on a non-invasively measured airflow into a subject's lungs; and determining the operation of respiration based on the determined intrapleural pressure and volume of the light subject and generating a signal representing the breath work. Also disclosed is a device for determining a physiological parameter, comprising: a parameter evaluation unit which evaluates the intrapleural pressure of the subject based on the non-invasively measured airway pressure of the subject and the non-invasively measured airflow into the subject's lungs by adjusting the lung mechanics model to said non-invasively measured airway pressure and non-invasively measured air flow into lungs and minimizing the sum of squared differences between non-invasively measured airway pressure and predicted airway pressure; and a quantitative determinant which determines the Campbell diagram based on the estimated intrapleural pressure and lung volume determined from the airflow into the lungs, and determines the respiration rate for the subject based on the area inside the pressure-volume loop and the chest wall stretchability line of the Campbell diagram.
EFFECT: group of inventions provides higher efficiency of determining a physiological parameter of a subject.
14 cl, 16 dwg
