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(19)

(11)

2 701 861

(13)

(51)

IPC

C07D209/00(2006-01-01)

C07D209/02(2006-01-01)

C07D209/52(2006-01-01)

A61K31/33(2006-01-01)

A61K31/40(2006-01-01)

A61K31/403(2006-01-01)

A61P17/04(2006-01-01)

(21) (22)

Application

2016121410, 2014-11-19

(24)

Start date

2014-11-19

(22)

Actual filing date

2014-11-19

(45)

Published

2019-10-02

(72)

Inventor

Taniko KaoriMiyadzava TosiyukiKaneko TatsurokhKurumadzuka DajsukeKharada SatokoIdzuti ToruOkabe MorioIvamura RioTsudzaki YasunoriSetoguti KhiroyukiImura YuukiAkadza KhirotoSimidzu MotokhisaKimura Tomio

(73)

Holder

Sanva Kagaku Kenkyuso Ko., Ltd.Ube Indastriz, Ltd.

NEW DERIVATIVE OF 3-AZABICYCLO[3.1.0]HEXANE AND USE THEREOF FOR MEDICAL PURPOSES Russian patent published in 2019 - IPC C07D209/00 C07D209/02 C07D209/52 A61K31/33 A61K31/40 A61K31/403 A61P17/04

Abstract RU 2701861 C1

FIELD: chemistry.

SUBSTANCE: objective of the present invention is to obtain a compound of formula (I), having p-opioid receptor antagonist action, which causes less side effects, hence, is less safe, or a pharmacologically acceptable salt thereof, and preparing a medicinal agent for use in preventing or treating itch based on antagonistic action on μ-opioid receptors.

EFFECT: disclosed is new 3-azabicyclo[3.1.0]hexane derivative and use thereof for medical purposes.

15 cl, 7 tbl, 42 ex

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RU 2 701 861 C1

Authors

Taniko Kaori

Miyadzava Tosiyuki

Kaneko Tatsurokh

Kurumadzuka Dajsuke

Kharada Satoko

Idzuti Toru

Okabe Morio

Ivamura Rio

Tsudzaki Yasunori

Setoguti Khiroyuki

Imura Yuuki

Akadza Khiroto

Simidzu Motokhisa

Kimura Tomio

Dates

2019-10-02—Published

2014-11-19—Filed