FIELD: chemistry.
SUBSTANCE: invention relates to a novel bicyclic or tricyclic heterocyclic compound of formula (I, where ring A is an optionally substituted aromatic group, one of X1 and X2 is a carbon atom, and other is nitrogen atom, X3 is a nitrogen atom or CR2, X4 is a nitrogen atom or CR3, X5 represents a sulphur atom or -CH = CH-, Z1 is an oxygen atom, -C(R6)(R7)-, -NH-, -C(R6)(R7)-NH-, -NH-C(R6)(R7)-, -C(R6)(R7)-O-, -OC(R6)(R7)- or a single bond, one of Z2 and Z3 is CH, and the other is a nitrogen atom, or both are nitrogen atoms, and other symbols have values defined in the description of invention, or its pharmacologically acceptable salt.
EFFECT: compound has inhibitory action on Kynurenine Aminotransferase-II (KAT-II), and can be used to produce a medicinal agent for treating cognitive impairment, neurodegenerative disease or schizophrenia.
22 cl, 3 tbl, 728 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DIAMINE DERIVATIVES | 2003 |
|
RU2333203C2 |
| NOVEL PYRIDOPYRIMIDINONE COMPOUNDS FOR MODULATION OF CATALYTIC ACTIVITY OF HISTONE LYSINE DEMETHYLASES (KDMS) | 2015 |
|
RU2684396C2 |
| CYCLOALKANE-1,3-DIAMINE DERIVATIVE | 2019 |
|
RU2793247C2 |
| DIAMINE DERIVATIVES | 2002 |
|
RU2314303C2 |
| SUBSTITUTED NICOTINIMIDE INHIBITORS OF BTK, THEIR PREPARATION AND USE IN TREATMENT OF CANCER, INFLAMMATION AND AUTOIMMUNE DISEASES | 2014 |
|
RU2677884C2 |
| ETHYLENEDIAMINE DERIVATIVES AND FXa INHIBITOR AND ANTICOAGULANT COMPRISING THEREOF | 2001 |
|
RU2268259C2 |
| DERIVATIVES OF DIAMINES | 2002 |
|
RU2319699C2 |
| PYRAZOLOPYRIMIDINE DERIVATIVE | 2007 |
|
RU2420530C2 |
| SUBSTITUTED TRICYCLIC COMPOUNDS AND METHOD OF APPLICATION | 2016 |
|
RU2744766C2 |
| DISPIROPYRROLIDINE DERIVATIVES | 2012 |
|
RU2612534C2 |
