STABILIZED PHARMACEUTICAL COMPOSITIONS OF INSULIN ANALOGUES AND/OR INSULIN DERIVATIVES Russian patent published in 2019 - IPC A61K9/08 A61K9/10 A61K38/28 A61K47/02 A61K47/08 A61K47/10 A61K47/42 A61P3/10 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, more specifically to a pharmaceutical formulation consisting of 3.5 mg/ml of aspartate, 1.72 mg/ml of metarecsole, 1.50 mg/ml of phenol, 0.04087 mg/ml of zinc chloride, 6.8 mg/ml of sodium chloride, 0.02 mg/ml of polysorbate 20, sodium hydroxide and/or hydrochloric acid to adjust pH to 7.4 and water. Also presented are a method of producing said pharmaceutical composition; a method of treating diabetes mellitus, a method of treating hyperglycemia and a method of reducing blood glucose by administering to a subject a given pharmaceutical formulation; as well as containing the declared pharmaceutical composition versions of kits for treating diabetes mellitus, hyperglycemia or for reducing blood glucose level and a medical device for administering the composition.

EFFECT: group of inventions provides stability of the composition based on the insulin analogue without including additional buffering agents.

20 cl, 1 dwg, 13 tbl, 3 ex