METHOD OF PRODUCING MONOSODIUM SALT OF ISOGLUTAMYL-TRYPTOPHAN Russian patent published in 2019 - IPC C07K1/107 C07K1/14 C07K5/37 C07K5/72 

FIELD: chemistry.

SUBSTANCE: invention relates to organic synthesis. Method includes steps of synthesis of carbobenzoxy-D-glutamic acid oxazolidinone, its condensation with methyl tryptophan, removal of carbobenzoxy protection with opening of oxalidinone ring by catalytic hydrogenolysis and alkaline saponification of methyl ether to obtain monosodium salt of dipeptide, characterized by that at the stage of synthesis of oxazolidinone carbobenzoxy-D-glutamic acid using washing with aqueous solution of hydroxylamine hydrochloride, and the step of removing carbobenzoxy protection with simultaneous opening of the oxalidine ring is carried out by catalytic hydrogenolysis over a palladium catalyst using formic acid as a hydrogen donor and aniline taken in amount of 2 to 4 equivalents with respect to the amount of the protected dipeptide.

EFFECT: disclosed is a method of producing D-isoglutamyl-D or L-tryptophan in form of a monosodium salt.

1 cl, 3 ex