METHOD FOR PRODUCING PEPTIDE EXENATIDE Russian patent published in 2012 - IPC C07K1/02 C07K1/06 C07K14/605 C07K14/575 A61K38/26 

Abstract RU 2458066 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine and chemical technology. What is offered is a method for producing the peptide Exenatide. The peptide Exenatide prepared by synthesis may be used for producing drugs for type 2 diabetes mellitus.

EFFECT: higher yield of the unpurified peptide (42%-60%), as well as higher purity (58%-75%) and content of the end product in a mixture (33%-42%); besides, a cheaper condensing agent (DIC) is used at all the condensation stages, while the synthesis of more than one short fragments simultaneously enables faster end peptide process.

3 cl, 2 tbl, 8 ex

Similar patents RU2458066C1

Title Year Author Number
PEPTIDE FOR MEDICAL TREATMENT OF PANCREATIC DIABETES OF 2ND TYPE AND ITS COMPLICATIONS 2014
  • Kashkin Vladimir Aleksandrovich
  • Makarov Valerij Gennad'Evich
  • Makarova Marina Nikolaevna
  • Shekunova Elena Vasil'Evna
  • Titov Mikhail Ivanovich
  • Eliseev Ivan Ivanovich
RU2573933C1
GLP-1 PEPTIDE HAVING ATTACHED OLIGOSACCHARIDE CHAIN 2008
  • Kadzikhara, Jasukhiro
  • Tsjudzi, Takasi
  • Sakamoto, Izumi
  • Nambu, Juri
  • Fukae, Kazukhiro
  • Tezuka, Katsunari
  • Asai, Khiroaki
RU2539829C2
EXENATIDE ANALOGUE 2020
  • Zhou, Shuliang
  • Wang, Peng
  • Deng, Lan
RU2823623C1
PROCESS FOR PREPARATION OF GLYCOPEPTIDE HAVING SIALYLATED SUGAR CHAIN, AND METHOD FOR PRODUCING SIALYL GLYCOASPARAGINE 2012
  • Kadzikhara Yasukhiro
  • Murakami Masumi
  • Isij Kadzuyuki
RU2586524C2
METHOD FOR PRODUCING PEPTIDES CONTAINING LIPOPHILICALLY MODIFIED LYSINE SIDE CHAIN 2017
  • Henkel, Bernd
  • Pleuss, Norbert
  • Hoerlein, Rolf-Ludwig
RU2755543C2
METHOD OF PRODUCING PEPTIDE 2008
  • Kadzikhara Jasukhiro
  • Sakamoto Izumi
  • Nambu Juri
  • Fukae Kazukhiro
  • Asai Khiroaki
RU2478105C2
SITE-SPECIFIC MONOPHYLATED ANALYGES OF EXCENDIN AND THE METHOD OF THEIR PRODUCTION 2012
  • Yue Pen
  • Yue Peng
RU2625015C2
GLP-1 ANALOGUE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND THEREOF APPLICATION 2010
  • Van Jali
  • Ljuj Ajfen
  • Sun' Chan'Gan'
  • Juan' Khehnli
RU2565536C2
ANALGESIC AGENT OF PEPTIDE STRUCTURE OF UNDERCAPEPTIDE CONTAINING D-OCTAARGININE VECTOR 2013
  • Titov Mikhail Ivanovich
  • Eliseev Ivan Ivanovich
  • Makarov Valerij Gennad'Evich
  • Makarova Marina Nikolaevna
  • Shekunova Elena Vasil'Evna
  • Kashkin Vladimir Aleksandrovich
RU2541127C1
GLYCATED PEPTIDE GLP-1 2009
  • Kadzikhara, Jasukhiro
  • Tsjudzi, Takasi
  • Sakamoto, Izumi
  • Nambu, Juri
  • Khajasi, Naokhiro
  • Isii, Kazujuki
  • Fukae, Kazukhiro
  • Tezuka, Katsunari
  • Asai, Khiroaki
RU2543157C2

RU 2 458 066 C1

Authors

Titov Mikhail Ivanovich

Eliseev Ivan Ivanovich

Gluzdikov Ivan Aleksandrovich

Nikol'Skaja Sof'Ja Konstantinovna

Dates

2012-08-10Published

2011-05-31Filed