FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to phosphonic salts based on salicylic and acetylsalicylic acids applicable in medicine and to a method for production thereof. Derivatives of formula
are proposed, where at R = Ac, n = 4, 5, 6, 9, 10; and with R = H, n = 4, 5, 9. Disclosed is a method of producing said derivatives, involving reaction in an inert atmosphere of haloalkyl esters of salicylic and acetylsalicylic acids of formula
where R and n are defined above, with excess of triphenylphosphine at boiling point of the solvent.
EFFECT: novel compounds effective as antibacterial and antioxidant agents with no toxic effect on the body.
7 cl, 2 tbl, 2 dwg
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Authors
Dates
2019-10-23—Published
2019-08-13—Filed