1-OMEGA-ARYLOXYALKYL AND 1-BENZYL-SUBSTITUTED 2-IMINOBENZIMIDAZOLINES AND PHARMACOLOGICALLY ACCEPTABLE SALTS THEREOF, HAVING ANTI-PROTIST AND ANTIMICROBIAL ACTIVITY Russian patent published in 2014 - IPC C07D235/14 A61K31/4184 A61P31/04 A61P33/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel 1-ω-aryloxyalkyl- and benzyl-substituted 2-iminobenzimidazolines and pharmacologically acceptable salts thereof of general formula 1 , where R = CH=CH₂, R¹ = 2-ClC₆H₄OCH₂ (1b); R = CH=CH₂, R¹ = 4-ClC₆H₄OCH₂ (1c); R = CH=CH₂, R¹ = 4-BrC₆H₄OCH₂ (1d); R = CH=CH₂, R¹ = 2,4-Cl₂C₆H₃OCH₂ (1e); R = CH=CH₂, R¹ = 3,4-Cl₂C₆H₃ (1f); R = CH=CH₂, R¹ = 4-FC₆H₄OCH₂CH₂ (1g); R = CH₂N(C₂H₅)₂, R¹ = 4-C(CH₃)₃C₆H₄OCH₂ (1h); R = CH₂N(C₂H₅)₂, R¹ = 3,4-Cl₂C₆H₃ (1i); R = R¹ = 4-OCH₃C₆H₄OCH₂ (1j); R = 4-BrC₆H₄, R¹ = 4-OCH₃C₆H₄OCH₂ (1k); R = 4-BrC₆H₄, R¹ =2-OCH₃C₆H₄OCH₂ (1l); R = 4-NO₂C₆H₄, R¹ = 4-OCH₃C₆H₄OCH₂ (1m); R = 3,4-Cl₂C₆H₃, R¹ = 2-OCH₃C₆H₄OCH₂ (1n); R = 3,4-Cl₂C₆H₃, R¹ = 4-OCH₃C₆H₄OCH₂ (1o); R = C₆H₅OCH₂, R¹ = 4-OCH₃C₆H₄OCH₂ (1p); R = 2-CH₃C₆H₄OCH₂, R¹ = 2-OCH₃C₆H₄OCH₂ (1q); R = 4-CH₃C₆H₄OCH₂, R¹ = 2-OCH₃C₆H₄OCH₂ (1r); R = 4-C(CH₃)3C₆H₄OCH₂, R¹ = 2-OCH₃C₆H₄OCH₂ (1s); R = 2-OCH₃C₆H₄OCH₂, R¹ = 4-BrC₆H₄OCH₂ (1t), having anti-protist and antibacterial activity.

EFFECT: obtaining novel compounds with useful biological activity.

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