QUINAZOLINE DERIVATIVES Russian patent published in 2019 - IPC C07D239/94 C07D403/12 A61K31/517 A61P35/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a novel compound of formula (I) and a pharmaceutically acceptable salt thereof. Compounds have the properties of a kinase activity inhibitor and can be used in preparing a drug for treating thyroid cancer, non-small cell carcinoma, epidermoid carcinoma, melanoma, colon cancer, gastric carcinoma, oesophageal cancer, pancreatic cancer, kidney cancer, liver cancer, lung cancer or ovarian cancer. In general formula (I)

,

R₁ is -O(CH₂)_nR₃, where n equals 3, 4 or 5; R₃ is NR^eR^f, where R^e and R^f each is independently selected from a group comprising C_1-6 alkyl, or R^e and R^f are joined together to form - (CH₂)₄-; R₂ is or Compounds of formula (I) are obtained by reacting a compound of formula (III) or a salt thereof with a compound of formula (IV) or a salt thereof in a solvent in the presence of one or more catalyst, base and surfactant according to the following scheme:

.

In said structural formulas R₁, R₂, R₃ and n are defined above, L is halogen, hydroxyl, mesyloxy or hydrogen and p = 0 or 1 with the proviso that when p = 1, L is hydrogen.

EFFECT: compounds of formula (I) show higher activity as compared to compounds with similar structure.

8 cl, 4 tbl, 37 ex