ISOQUINOLINONE DERIVATIVES USEFUL IN TREATING CANCER Russian patent published in 2019 - IPC C07D471/04 A61K31/519 A61P35/00 

Abstract RU 2690853 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: present invention relates to a compound of formula (I):

or a pharmaceutically acceptable salt thereof, where X, R0, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are defined in claim 1. Invention also relates to a method of producing said compound of formula (I), use thereof for preparing a medicament for treating cancer, where JAK and/or FLT3 inhibition may be useful, to use thereof for preparing a medicament for treating leukemia, particularly acute myeloid leukemia, as well as to a pharmaceutical composition for use in treating cancer, where inhibition of JAK and/or FLT3 containing said compound can be beneficial.

EFFECT: technical result is creation of new and more powerful double FLT3-JAK inhibitors, providing the best result for patients with high risk of acute myeloid leukemia.

19 cl, 3 tbl

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RU 2 690 853 C2

Authors

Kalun El Bakhir

Shmitt Filipp

Kryuzinski Anna

Dates

2019-06-06Published

2015-09-02Filed