BICYCLIC COMPOUNDS, METHOD OF INHIBITION OF PLATELET ADHESION AND COMPOSITION FOR ITS REALIZATION Russian patent published in 2001 - IPC

Abstract RU 2169146 C2

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel compounds with nucleus formed by two condensed six-membered rings A and B of the formula (I) or pharmaceutically acceptable salt, solvate or prodrug derivative of this compound where bicyclic nucleus with rings A and B is taken among the group consisting of the formulas (17) , (18) , (19) , (20) , (21) ; R3 is an acidic group containing acidic radical taken among formulas of the group (C) ; n = 0-6; Ro is similar or distinct and taken independently from hydrogen atom, alkyl; binding group -(L)- is a bond or taken among formulas: -C(=O)-N(H)- and -C(H2)-O-; Q is basic group and taken among amidino-group and piperidine. New bicyclic compounds are useful as preparations neutralizing effect of glycoprotein IIb/IIIa for thrombosis prevention. Invention describes also method of inhibition of platelets adhesion and composition for its realization. EFFECT: new compounds indicated above, improved method of inhibition, valuable medicinal properties. 25 cl, 1 tbl, 105 ex

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RU 2 169 146 C2

Authors

Fisher Matt'Ju Dzhozef

Jakubovski Dzhozef Antoni

Martinelli Mikaehl Dzhon

Morin Dzhon Mikaehl Ml.

Paal Mikaehl

Rjuter Gerd

Ruterbories Kennet Dzhams

Skotten Teo

Stenzel Vol'Fgang

Vasileff Robert Teodore

Dates

2001-06-20Published

1996-01-18Filed