FIELD: medicine; therapy.
SUBSTANCE: group of inventions relates to the field of medicine, namely to therapy; it is intended for the treatment of cardiovascular diseases, disorders of fatty acid metabolism and glucose use, gastrointestinal diseases, and liver diseases. Derivatives of 1,5-benzothiazepine and 1,2,5-benzothiadiazepine of the formula (I) are presented. In another implementation, a pharmaceutical composition is provided, containing these compounds.
EFFECT: group of inventions provides new derivatives of 1,5-benzothiazepine and 1,2,5-benzothiadiazepine of the formula (I), as well as a pharmaceutical composition containing these compounds, which are bile acid modulators having inhibitory activity relatively to an apical sodium-dependent bile acid transporter (ASBT) and/or a liver bile acid transporter (LBAT).
15 cl, 7 tbl, 110 ex
| Title |
Year |
Author |
Number |
| BENZOTHIAZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS |
2020 |
- Gillberg, Per-Joran
- Mattson, Yan
- Starke, Ingemar
- Kulkarni, Santosh S.
|
RU2817535C2 |
| 1,5-BENZOTHIAZEPINES AND EMPLOYMENT THEREOF AS ANTIHYPERLIPIDEMIC DRUGS |
2001 |
- Starke Ingemar
- Dal'Strom Mikaehl'
- Blomberg David
|
RU2302414C2 |
| BENZOTHIADIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACIDS MODULATORS |
2020 |
- Gillberg, Per-Joran
- Mattson, Yan
- Starke, Ingemar
- Kulkarni, Santosh S.
|
RU2814570C2 |
| ORTHO-SUBSTITUTED DERIVATIVES OF BENZOIC ACID, METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND USING |
2003 |
|
RU2288912C2 |
| BICYCLIC TETRAHYDROTHIAZEPINE DERIVATIVES USEFUL FOR TREATING NEOPLASTIC AND/OR INFECTIOUS DISEASES |
2016 |
- Ermann Monika
- Lametshvandtner Gyunter
- Amoutseg Patrisia Leoni
- Kraft Rassell Styuart
- Khanke Tomas
- Dzhejms Timoti Robin
- Dzhouns Severin Daniel
- Lojbner Khans
- Loke Puj Leng
- Shternberger Ina
- Shtyutts Anton
- Ver Roland
- Uittejker Mark
|
RU2730524C2 |
| DERIVATIVES OF SUBSTITUTED PHENYLPROPIONIC ACID AS AGONISTS OF HUMAN ALPHA-RECEPTOR (PPARα) ACTIVATED BY PEROXISOME PROLIFERATORS, METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHODS FOR DYSLIPIDEMIA TREATMENT AND TYPE 2 DIABETES MELLITUS |
2002 |
- Al'Stermark Lindstedt Ehva-Lotte
- Ol'Sson Anna Kristina
- Li Lanna
|
RU2300517C2 |
| DERIVATIVES OF SUBSTITUTED PHENYLPROPIONIC ACID AS AGONISTS OF HUMAN ALPHA-RECEPTORS ACTIVATED BY PEROXISOME PROLIFERATOR (PPARα), METHOD AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, THEIR USING AND METHODS FOR TREATMENT OF DYSLIPIDEMIA IN DIABETES MELLITUS TYPE 2 |
2002 |
- Al'Stermark Lindstedt Ehva-Lotte
- Ol'Sson Anna Kristina
- Li Lanna
|
RU2303031C2 |
| BENZOTHIADIAZEPINE DERIVATIVES AND METHOD FOR PRODUCTION THEREOF (VARIANTS) |
2002 |
- Starke Ingemar
- Dal'Strum Mikaehl' Ul'F Jukhan
- Blumberg David
- Alenfal'K Suzanne
- Sharet Ture
- Lemurell' Malin
|
RU2305681C2 |
| BENZOIC ACID DERIVATIVES AS PPAR α AND PPAR λ MODULATORS |
2003 |
|
RU2339613C2 |
| 1,4-BENZOTHIAZEPINE-1,1-DIOXIDE, PHARMACEUTICAL COMPOSITION DECREASING BLOOD LIPID LEVEL, METHOD OF TREATMENT OF MAMMAL CLINICAL STATE, METHOD OF SYNTHESIS OF COMPOUND |
1995 |
|
RU2156245C2 |
