FIELD: medicine; therapy.
SUBSTANCE: group of inventions relates to the field of medicine, namely to therapy; it is intended for the treatment of cardiovascular diseases, disorders of fatty acid metabolism and glucose use, gastrointestinal diseases, and liver diseases. Derivatives of 1,5-benzothiazepine and 1,2,5-benzothiadiazepine of the formula (I) are presented. In another implementation, a pharmaceutical composition is provided, containing these compounds.
EFFECT: group of inventions provides new derivatives of 1,5-benzothiazepine and 1,2,5-benzothiadiazepine of the formula (I), as well as a pharmaceutical composition containing these compounds, which are bile acid modulators having inhibitory activity relatively to an apical sodium-dependent bile acid transporter (ASBT) and/or a liver bile acid transporter (LBAT).
15 cl, 7 tbl, 110 ex
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