FIELD: chemistry.
SUBSTANCE: invention relates to 2-substituted 5-hydroxypyrano[2,3-d][1,3]oxazine-4,7-diones, which can be used in medical industry, of general formula I
(I),
where R = phenyl, 4-methylphenyl, 4-bromophenyl, 4-nitrophenyl, 4-methoxyphenyl, 3-methoxyphenyl, styryl, furan-2-yl. Disclosed is a method of producing said compounds by reacting amides of corresponding carboxylic acids selected from benzamide, p-methylbenzamide, p-bromobenzamide, p-nitrobenzamide, p-methoxybenzamide, m-methoxybenzamide, styrylamide, furylamide, with malonyl chloride in molar ratio of 1:2 in an environment of an anhydrous polar organic solvent (tetrahydrofuran), stirring the reaction mass for 12–25 hours at room temperature, filtering the obtained residue.
EFFECT: disclosed are novel antibacterial compounds and a novel efficient method of producing said compounds.
3 cl, 6 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED 2-(1-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)-3-PHENYL-1H-1,2,4-TRIAZOL-5-YL)PROPANOIC ACIDS AND METHOD FOR THEIR PRODUCTION | 2017 |
|
RU2645683C1 |
| SUBSTITUTED 2-(1,3-BENZOTHIAZOL-2-YL)-3-PHENYL-1H-1,2,4-TRIAZOL-5-YL) PROPANOIC ACIDS AND SYNTHESIS METHOD THEREOF | 2015 |
|
RU2603958C1 |
| SUBSTITUTED 2,2'-[(6-METHYLPYRIMIDINE-2,4-DIYL)BIS(3-PHENYL-1N-1,2,4-TRIAZOL-1,5-DIYL)]DIPROPANIC ACIDS AND METHOD OF THEIR PRODUCTION | 2016 |
|
RU2631325C1 |
| 2,4-DIARYL-6-ALKYL-1,3,5-TRIAZINES AND METHOD OF THEIR PREPARATION | 2023 |
|
RU2812149C1 |
| METHOD OF PREPARING 5-OXY-3-ARYL-1,2-OXAZIN-6-ONES | 0 |
|
SU819102A1 |
| HETEROCYCLIC INHIBITORS OF Hh-SYGNAL CASCADE, BASED ON THEM MEDICINAL COMPOSITIONS AND METHOD OF TREATING DISEASES INDUCED BY ABBARANT ACTIVITY OF Hh-SIGNAL SYSTEM | 2007 |
|
RU2364597C1 |
| 2-ARYL-6-(METHYLTHIO)-4-CHLORO-2H-PYRAZOLO[3,4-D]PYRIMIDINES AND A METHOD FOR PRODUCTION THEREOF | 2019 |
|
RU2708892C1 |
| 0 |
|
SU419036A3 | |
| 4-[(4-BROMOPHENYL)((4-NITROPHENYL)AMINO)METHYLIDENE]-5-HYDROXY-5-(TRICHLOROMETHYL)DIHYDROFURAN-2,3-DIONE WITH ANTIMICROBIAL ACTIVITY | 2022 |
|
RU2783242C1 |
| 6-ARYL-5-QUINOXALYL-2H-1,3-OXAZINE-4-ONES ELICITING FLUORESCENT PROPERTY AND METHOD FOR THEIR PREPARING | 2003 |
|
RU2240320C1 |
