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2 645 683

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IPC

C07D403/04(2006-01-01)

A61K31/4196(2006-01-01)

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Application

2017119891, 2017-06-06

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Start date

2017-06-06

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Actual filing date

2017-06-06

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Published

2018-02-27

(72)

Inventor

Ovsyannikova Liliya NikolaevnaLalaev Boris YurevichYakovlev Igor PavlovichFam An TuanKirillova Evgeniya NikitichnaKuvaeva Elena Vladimirovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Gosudarstvennaya Khimiko-Farmatsevticheskaya Akademiya" Ministerstva Zdravookhraneniya Rossijskoj Federatsii Vo Spkhfa Minzdrava Rossii)

SUBSTITUTED 2-(1-(3-OXO-3,4-DIHYDROQUINOXALIN-2-YL)-3-PHENYL-1H-1,2,4-TRIAZOL-5-YL)PROPANOIC ACIDS AND METHOD FOR THEIR PRODUCTION Russian patent published in 2018 - IPC C07D403/04 A61K31/4196

Abstract RU 2645683 C1

FIELD: pharmacology.

SUBSTANCE: invention relates to 2-(1-(3-oxo-3,4-dihydroquinoxalin-2-yl)-3-phenyl-1H-1,2,4-triazol-5-yl)propanoic acids of general formula I where R=NO₂ (Ia - 2-(3-(4-nitrophenyl)-1-(3-oxo-3,4-dihydroquinoxalin-2-yl)-1H-1,2,4-triazol-5-yl)propanoic acid; R=OCH₃ (Ib - 2-(3-(4-methoxyphenyl)-1-(3-oxo-3,4-dihydroquinoxalin-2-yl)-1H-1,2,4-triazol-5-yl)propanoic acid; R=CH₃ (Ic - 2-(3-(4-methylphenyl)-1-(3-oxo-3,4-dihydroquinoxalin-2-yl)-1H-1,2,4-triazol-5-yl)propanoic acid; R=H (Id - 2-(1-(3-oxo-3,4-dihydroquinoxalin-2-yl)-3-phenyl-1H-1,2,4-triazol-5-yl)propanoic acid. The invention also relates to a method for their preparation.

EFFECT: new compounds are obtained that can be used as antimicrobial agents.

2 cl, 2 tbl, 5 ex

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RU 2 645 683 C1

Authors

Ovsyannikova Liliya Nikolaevna

Lalaev Boris Yurevich

Yakovlev Igor Pavlovich

Fam An Tuan

Kirillova Evgeniya Nikitichna

Kuvaeva Elena Vladimirovna

Dates

2018-02-27—Published

2017-06-06—Filed