2-ARYL-6-(METHYLTHIO)-4-CHLORO-2H-PYRAZOLO[3,4-D]PYRIMIDINES AND A METHOD FOR PRODUCTION THEREOF Russian patent published in 2019 - IPC C07D471/04 A61K31/519 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to organic and medical chemistry and specifically to novel compounds of the class of heterocyclic systems – derivatives of 2-aryl-6-(methylthio)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine, of general formula I, where R=H, R₁=phenyl (Ia) – 6-(methylthio)-2-phenyl-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=2-bromophenyl (1b) – 2-(2-bromophenyl)-6-(methylthio)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=2-methylphenyl (Ic) – 6-(methylthio)-2-(2-methylphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=2-methoxyphenyl (Id) – 6-(methylthio)-2-(2-methoxyphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=2-nitrophenyl (Ie) – 6-(methylthio)-2-(2-nitrophenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=3-bromophenyl (If) – 2-(3-bromophenyl)-6-(methylthio)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=3-methylphenyl (Ig) – 6-(methylthio)-2-(3-methylphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=3-methoxyphenyl (Ih) – 6-(methylthio)-2-(3-methoxyphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=3-nitrophenyl (Ii) – 6-(methylthio)-2-(3-nitrophenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=4-bromophenyl (Ij) – 2-(4-bromophenyl)-6-(methylthio)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=4-methylphenyl (Ik) – 6-(methylthio)-2-(4-methylphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=4-methoxyphenyl (Il) – 6-(methylthio)-2-(4-methoxyphenyl)-4-chloro-2H-pyrazolo[3,4-d]pyrimidine. Invention also relates to a method of producing a compound of formula (I).

EFFECT: obtaining novel heterocyclic compounds having antimicrobial activity.

2 cl, 1 dwg, 13 ex