2,4-DIARYL-6-ALKYL-1,3,5-TRIAZINES AND METHOD OF THEIR PREPARATION Russian patent published in 2024 - IPC C07D251/24 A61K31/53 A61P31/10 

Abstract RU 2812149 C1

FIELD: organic chemistry.

SUBSTANCE: invention relates to new 2,4-diaryl-6-alkyl-1,3,5-triazines of general formula I, where R=NO2, Cl, CH3, OCH3. The invention also relates to a method of their preparation by cleavage of the corresponding 2,5-disubstituted-4-hydroxy-6H-1,3-oxazin-6-ones with benzamidine hydrochloride in the presence of an equimolar amount of sodium propoxide in boiling propanol for 2–4 hours with subsequent treatment of the reaction mass with a 10% sodium hydroxide solution and isolation of the target product from the suspension.

EFFECT: obtaining new compounds of general formula I, which can be used in medicine as antifungal (antimycotic) agents.

3 cl, 4 tbl, 5 ex

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RU 2 812 149 C1

Authors

Levshukova Polina Olegovna

Kolesnik Denis Andreevich

Kuvaeva Elena Vladimirovna

Yakovlev Igor Pavlovich

Tunguskova Lidiya Aleksandrovna

Ksenofontova Galina Vladimirovna

Kirillova Evgeniya Nikitichna

Dates

2024-01-23Published

2023-06-06Filed