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(19)

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2 705 540

(13)

(51)

IPC

C07K16/38(2006-01-01)

C12N15/13(2006-01-01)

A61K39/395(2006-01-01)

A61P7/02(2006-01-01)

(21) (22)

Application

2018104283, 2016-08-10

(24)

Start date

2016-08-10

(22)

Actual filing date

2016-08-10

(45)

Published

2019-11-07

(72)

Inventor

Apgar James R.Benard SusanCarven Gregory J.Hett Sunita R.Holsti MatthewJasuja ReemaJin MacyJuo Zong SeanPittman DebraStahl Mark

(73)

Holder

Pfizer Inc.

ANTIBODIES AGAINST TISSUE FACTOR PATHWAY INHIBITOR AND USE THEREOF Russian patent published in 2019 - IPC C07K16/38 C12N15/13 A61K39/395 A61P7/02

Abstract RU 2705540 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: present invention relates to immunology. Antibodies specifically binding to an epitope in Kunitz 2 (K2) domain and their antigen-binding fragments are disclosed. Also disclosed are nucleic acid molecules encoding said antibodies or fragments thereof; pharmaceutical composition, methods for reducing tissue factor (TFPI) inhibitor activity and methods for reducing haemorrhage.

EFFECT: antibodies and their fragments according to the present invention can be used in treating bleeding disorders and reducing blood coagulation time.

33 cl, 14 dwg, 33 tbl, 18 ex

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RU 2 705 540 C2

Authors

Apgar James R.

Benard Susan

Carven Gregory J.

Hett Sunita R.

Holsti Matthew

Jasuja Reema

Jin Macy

Juo Zong Sean

Pittman Debra

Stahl Mark

Dates

2019-11-07—Published

2016-08-10—Filed