USE OF POLYMER EXCIPIENTS FOR LYOPHILIZATION OR FREEZING OF PARTICLES Russian patent published in 2019 - IPC A61K9/19 A61K31/337 A61K47/32 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: group of inventions relates to the pharmaceutical industry, in particular to a method of producing a pharmaceutical composition, according to which to an aqueous composition comprising solid particles, adding sugar and polyvinyl alcohol (PVA) with molecular weight of 13–31 kDa, and then lyophilising or freezing the obtained aqueous composition, where: solid particles contain a drug with solubility in water of less than 1 mg/ml at 25 °C and a polymer, wherein the particles are coated with polyethylene glycol (PEG) attached to the polymer; concentration of PVA in the aqueous solid particles composition is 0.05–1 wt./vol.; and less than 2 wt./wt. of total amount of PVA in composition is related to solid particles. Also disclosed are versions of the pharmaceutical composition and use of the pharmaceutical composition for treating cancer.

EFFECT: group of inventions provides preventing particle aggregation and/or increasing their size when lyophilising or freezing a pharmaceutical composition.

37 cl, 3 ex, 5 tbl