FIELD: chemistry.
SUBSTANCE: group of inventions relates to the chemical-pharmaceutical industry and is a method of preventing antibody oxidation in a pharmaceutically stable liquid formulation and the pharmaceutically stable liquid formulation itself containing an antibody and a compound which prevents oxidation of the antibody in the liquid formulation, wherein the compound is selected from a group consisting of 5-hydroxy-tryptophan, 5-hydroxy indole, 7-hydroxy indole and serotonin. Invention also relates to a method of producing said pharmaceutically stable liquid formulation.
EFFECT: group of inventions enables to provide antioxidant activity of the antibody without decomposition with formation of reactive oxygen species.
32 cl, 10 dwg, 3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOSITIONS WITH REDUCED OXIDATION | 2014 |
|
RU2707550C2 |
| METHODS FOR CELL CULTIVATION | 2018 |
|
RU2758674C2 |
| METHOD FOR OBTAINING BI-SPECIFIC ANTIBODIES, BI-SPECIFIC ANTIBODIES AND THERAPEUTIC APPLICATION OF SUCH ANTIBODIES | 2018 |
|
RU2795240C2 |
| COMPOSITIONS AND METHODS, INCLUDING ALKYLGLYCOSIDES, FOR STABILISATION OF PROTEIN-CONTAINING COMPOSITIONS | 2011 |
|
RU2575830C2 |
| PROCOAGULANT ANTIBODIES | 2018 |
|
RU2810094C2 |
| ANTIBODY PURIFICATION METHODS | 2017 |
|
RU2759909C2 |
| ANTI-TFR ANTIBODIES AND USE THEREOF IN TREATING PROLIFERATIVE AND INFLAMMATORY DISORDERS | 2016 |
|
RU2737637C2 |
| POLY-SPECIFIC ANTIBODY STRUCTURES | 2015 |
|
RU2784673C2 |
| STRUCTURE OF POLYPEPTIC ANTIBODIES | 2015 |
|
RU2725812C2 |
| ANTIBODIES TO BTN3A AND THEIR USE IN THE TREATMENT OF CANCER OR INFECTIOUS DISEASES | 2019 |
|
RU2800726C2 |
