FIELD: biotechnology.
SUBSTANCE: present invention relates to the field of biotechnology, specifically to the use of limited amount of cysteine and tryptophan as an additive to the medium for cell cultivation during the production of recombinant proteins and, in particular, antibodies.
EFFECT: proteins and antibodies obtained under such controlled conditions have reduced heterogeneity, in particular, reduced heterogeneity of charged options.
30 cl, 18 dwg, 8 tbl, 9 ex
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