FIELD: medicine.
SUBSTANCE: invention refers to medicine, namely to oncology and can be used for reduction of oncological pain in cancer patients of various localization with a common process. Method comprises administering to patient T1-4N1-3M1 with different localization of the first allogenic dendritic cell vaccine malignant process paravertebral at level C7-Th2 intradermally of 4 points of 0.3 ml, wherein total number of dendritic cells is 5,000,000. 2 weeks after the introduction of the first vaccine, a second allogenic dendritic cell vaccine is administered in a similar way, with a total number of 10,000,000 dendritic cells, thus the number of dendritic cells in total is equal to 15,000,000 in two sessions of vaccine therapy. Two weeks after the second introduction, the third allogenic dendritic cell vaccine is administered by 0.3 ml in a similar way; the total number of dendritic cells is 5,000,000. Two weeks after the third introduction of the dendritic cell vaccine, a fourth allogenic dendritic cell vaccine is administered by 0.3 ml in a total dosage of 10,000,000 cells. Thus, for 3 and 4 sessions of vaccine therapy patient receives 15,000,000 cells, wherein in one course of vaccine therapy patient receives 30,000,000 dendritic cells. Immunotherapy in the above mode is carried out for one year, in the absence of contraindications to the patient in parallel to the immunotherapy, the chemotherapy courses recommended for the given localization of the malignant process are conducted, wherein the first chemotherapy course is started one week before the first dendritic cell vaccine introduction, if there are contraindications to the chemotherapy, the vaccine therapy is performed in an independent mode.
EFFECT: use of the invention enables reducing oncological pain, thereby improving the quality of life of incurable oncological patients.
1 cl, 2 ex
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Authors
Dates
2019-12-02—Published
2019-01-24—Filed