FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology. Proposed are antibody drug conjugates (ADC) in which the antibody is an antibody specific for Delta-like ligand 3 (DLL3) and covalently linked through a linker with one or more pyrrolobenzodiazepines (PBDs). Also proposed are: a pharmaceutical composition, kits, a method for treating DLL3-associated cancer, a method for reducing the frequency of tumor-initiating cells, and a method for delivering PBD to a DLL3-associated cancer cell.
EFFECT: this invention may find further application in therapy.
34 cl, 6 dwg, 5 tbl, 10 ex
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