USING RADIOPHARMACEUTICAL COMPOSITION USING LABELLED AUTOLOGOUS LEUKOCYTES TO VISUALIZE LOCAL RADIATION LESIONS BY SINGLE-PHOTON EMISSION TOMOGRAPHY Russian patent published in 2019 - IPC A61K35/15 A61K103/20 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to using a radiopharmaceutical composition using labelled autologous leukocytes to visualize local radiation lesions by single-photon emission tomography. For this purpose, leukocyte labelling is performed by a radiopharmaceutical composition based on ¹¹¹In, characterized by the following composition: indium - 11135–40 MBq, 8 - hydroxyquinoline 0.05 mg, sodium hydrocarbonate 6.72 mg, dextran with molecular weight from 30,000 to 50,000 - 30.0 mg, mannitol 15.0 mg, sodium chloride 2.7 mg, hydrochloric acid 0.05 M to 1 ml.

EFFECT: invention provides high efficiency of labelling autologous leukocytes with a radiopharmaceutical composition containing as active ingredient ¹¹¹In, with visualization up to two days in the local radiation injury centre, which enables to perform single-photon emission computed tomography (SPECT) procedures for several days without additional administration of the radiopharmaceutical.

1 cl, 1 dwg, 1 tbl, 4 ex