OSTEOTROPIC RADIOPHARMACEUTICALS FOR PET IMAGING Russian patent published in 2017 - IPC A61K49/00 A61K51/04 A61K103/00 

FIELD: medicine.

SUBSTANCE: invention relates to the field of nuclear medicine, namely to radiopharmaceuticals (RF) for metastatic bone lesions imaging using the positron emission tomography (PET) techniques and radiation therapy planning. This goal is achieved by application of a composition representing a solution containing gallium-68 in the form of a complex with oxa-bis (ethylene-nitrile)tetrametylene-phosphonic acid and sodium chloride, sodium hydroxide and a phosphate buffer containing sodium phosphate and sodium hydrogen phosphate, as the preparation for PET imaging of metastatic bone lesions and radiation therapy planning. Preparation is obtained from a lyophilized composition at the room temperature during 1-2 minutes, radiochemical purity of the preparation is more than 90%, pH range is from 4.5 to 8.0, maximum accumulation of drug in a pathological bone shall be reached 1.5 hours after introduction, and is 40-45% of the introduced activity, differential callus/blood accumulation factor is more than 10, accumulation of the drug in blood is less than 0.30%/year.

EFFECT: invention expands the number of nuclear medicine devices, particularly for metastatic bone lesions imaging using the positron emission tomography (PET) techniques and radiation therapy planning.

3 dwg, 4 ex, 1 tbl