METHOD FOR ASSESSING THE EFFECTIVENESS OF CHEMOTHERAPY FOR MALIGNANT LYMPHOMAS Russian patent published in 2019 - IPC A61B6/03 A61K51/00 A61K103/10 A61P43/00 

FIELD: medicine.

SUBSTANCE: invention refers to medicine, namely to oncology and radiation diagnostics, and can be used for assessing the effectiveness of chemotherapy for malignant lymphomas. One-photon emission computed tomography (OPECT) is performed twice: before and two weeks after completion of chemotherapy in patients with initially high accumulation of radiopharmaceutical (RP) in the tumor. That is ensured by administering a radiopharmaceutical preparation based on technetium-99m-labeled glucose derivative prepared immediately before administration. For this purpose 4 ml of sodium pertechnetate Na^99mTcO₄ from a generator under aseptic conditions is introduced by means of a syringe into a bottle with a reagent consisting of: 1-thio-D-glucose sodium salt of hydrate 0.625 mg, tin dichloride 2-water 0.044–0.052 mg, ascorbic acid not more than 0.125 mg, sodium chloride 8.0–10.0 mg, water for injection up to 1 ml. Content of the vial is mixed by shaking, incubated at room temperature for 30 minutes until complete dissolution of the reagent. Intravenous is administered RP in dose of 500 MBq. In 40 minutes after administration RP one-photon emission computed tomography is carried out on a two-detector gamma camera. Obtained images are subjected to postprocessing. In the absence of hyperfixation foci RP repeated reassessment involves complete remission of malignant lymphoma. Presence of hyperfixation areas RP in tissue of lymph nodes and extranodally indicates resistance of malignant lymphoma to chemotherapy.

EFFECT: high information value and accessibility of the method.

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