METHOD OF PRODUCING IMMUNOGLOBULINS Russian patent published in 2019 - IPC C07K16/06 C07K1/34 A61K39/395 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to a method of producing an immunoglobulin solution. Method for producing a solution of immunoglobulins from an initial immunoglobulin solution with a degree of purity of not less than 96 %, concentration of 1 to 10 mg/ml, containing 2 to 6 % (w/v) polyethylene glycol (PEG) or polypropylene glycol (PPG), comprises steps a) adding caprylic acid or salts thereof to the initial solution until reaching concentration of 9 to 15 mM; b) bringing pH of solution obtained at step a) to pH 5.0–5.2; c) incubating the solution obtained at step b) for a period of time and at a temperature required to inactivate envelope viruses; and d) performing the step of ultrafiltration/diafiltration of the solution obtained at step c). Also disclosed is the use of caprylic acid for virus inactivation.

EFFECT: group of inventions provides using a lower concentration of caprylate for virus inactivation when producing an immunoglobulin solution, which enables to avoid or does not cause aggregation.

19 cl, 11 tbl, 9 ex