METHOD OF PRODUCING ACTIVE PHARMACEUTICAL SUBSTANCE ZIRCONIUM-89 FOR RADIOPHARMACEUTICAL DRUGS Russian patent published in 2019 - IPC A61K51/00 A61K51/04 C07F7/00 C07C55/07 C07C55/22 C07C51/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to a method of producing an active pharmaceutical substance of zirconium-89 in form of [⁸⁹Zr]Zr-oxalate and [⁸⁹Zr]Zr-citrate for radiopharmaceutical drugs. Method includes following steps: interaction ⁸⁹Zr-chloride in 2–6 M HCl with hydroxamate resin, at which sorption of zirconium-89 takes place, washing of hydroxamate resin with precipitated zirconium-89, elution of zirconium-89 from hydroxamate resin with oxalic acid solution (0.1–1.0 M), reacting the obtained eluate with a chelate ion-exchange resin, washing the ion-exchange resin with subsequent drying thereof with air or an inert gas, desorption of zirconium-89 with aqueous solutions of sodium oxalate with concentration of 0.05–0.27 M or sodium citrate with concentration of 0.05–1.0 M volume 1 ml.

EFFECT: disclosed invention enables to obtain zirconium-89 solutions of high purity and can be used for synthesis of radiopharmaceutical drugs used in positron emission tomography (PET).

1 cl, 5 dwg, 1 tbl, 4 ex