1-BENZOYL-SUBSTITUTED-6-(METHYLTHIO)-4-CHLORO-1H-PYRAZOLO[3,4-D]PYRIMIDINES AND A METHOD FOR PRODUCTION THEREOF Russian patent published in 2019 - IPC C07D471/04 A61K31/519 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to organic and medical chemistry, specifically to novel 1-benzoyl-substituted-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine derivatives of general formula I, where R=H, R₁=phenyl (Ia) – 1-benzoyl-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d] pyrimidine; R=H, R₁=2-bromophenyl (Ib) – 1-(2-bromobenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=2-methylphenyl (Ic) – 1-(2-methylbenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=2-methoxyphenyl (Id) – 1-(2-methoxybenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=3,4-dimethoxyphenyl (Ie) – 1-(3,4-dimethoxybenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=3-bromphhenyl (If) – 1-(3-bromobenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=3-methylphenyl (Ig) – 1-(3-methylbenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=3-methoxyphenyl (Ih) – 1-(3-methoxybenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=4-bromphhenyl (Ii) – 1-(4-bromobenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=4-methylphenyl (Ij) – 1-(4-methylbenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4 d]pyrimidine; R=H, R₁=4-methoxyphenyl (Ik) – 1-(4-methoxybenzoyl)-6-(methylthio)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=2-furyl (Il) – 6-(methylthio)-1-(2-furoyl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine; R=H, R₁=2-thienyl (Im) – 6-(methylthio)-1-(2-thienylcarbonyl)-4-chloro-1H-pyrazolo[3,4-d]pyrimidine. Invention also relates to a method of producing a compound of formula (I).

EFFECT: obtaining novel heterocyclic compounds having antimicrobial activity.

2 cl, 14 ex